PAPER OF THE MONTH - MARCH 2020
Does viral load affect the severity of respiratory syncytial virus (RSV) disease in children?
Uusitupa E, Waris M, Heikkinen T.
Over the past years results on the associations between RSV loads and severe manifestations of the RSV illness were contradictory. Nevertheless, association between viral load and severity of illness in contributive for the use of antivirals in RSV disease. Heikkinen and colleagues conducted a prospective cohort study of respiratory outpatient naturally infected children. During each episode of respiratory illness, children were clinically examined, nasal swaps for virus sampling were taken and daily symptoms were recorded. In 201 new onset RSV infections, Heikkinen and colleagues show that children with higher viral load had significantly longer durations of respiratory compared to children with lower viral load. The findings in this largest outpatient study so far on this topic, support the concept that viral load drives the severity of RSV disease in children. RSV infected children might benefit of the reduction of RSV viral load by RSV antivirals.
Uusitupa E, Waris M, Heikkinen T.
Over the past years results on the associations between RSV loads and severe manifestations of the RSV illness were contradictory. Nevertheless, association between viral load and severity of illness in contributive for the use of antivirals in RSV disease. Heikkinen and colleagues conducted a prospective cohort study of respiratory outpatient naturally infected children. During each episode of respiratory illness, children were clinically examined, nasal swaps for virus sampling were taken and daily symptoms were recorded. In 201 new onset RSV infections, Heikkinen and colleagues show that children with higher viral load had significantly longer durations of respiratory compared to children with lower viral load. The findings in this largest outpatient study so far on this topic, support the concept that viral load drives the severity of RSV disease in children. RSV infected children might benefit of the reduction of RSV viral load by RSV antivirals.
On 12- 14 November 2019 ReSViNET Foundation heldt its 5th conference: “RSVVW 2019 - A Global Conference on Novel RSV Preventive and Therapeutic Interventions" in Accra, Ghana. We look back on a successful, exciting and inspiring meeting. Our special thanks to our sponsors to make this event possible and our chairs and scientific advisory board. Last but not least we thank all the speakers and participants for their contributions. |
AWARENESS OF RSV AS A GLOBAL HEALTH PROBLEM IS LACKING
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To raise and spread awareness, we have launched a ‘RSV Mortality Awareness’ campaign at the start of the RSVVW2019 conference on November 12, by sharing a personal video entitled “Why we should all know about RSV” about Simone van Wyck, a mother who lost her son due to RSV. The RSV awareness video was produced in collaboration with the Bill & Melinda Gates Foundation.
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We would like to express our sincere condolences to Neeltjes' family for their loss. Jan. 2020.
Neeltje from The Netherlands, 99 years old, participant of the RESCEU Older adults study. RSV is an important cause of pneumonia in older adults. Awareness of RSV in older adults is almost absent. Every year about 3-6% of all older adults are infected with RSV. Course of disease is most severe on older adults with severe underlying disease such as heart failure or COPD. |
ABOUT RESVINET FOUNDATIONRSV (Respiratory Syncytial Virus) infection is the second most important cause of death during infancy, especially in developing countries. |
ReSViNET Foundation is certified by NGOsource as equivalent to a U.S. public charity!
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