Ruben J. Geerdink, MSc; Marije P. Hennus, PhD, MD; Geertje H. A. Westerlaken, BSc; Alferso C. Abrahams, MD; Kim I. Albers, MD; Jona Walk, MD; Esther Wesselink, MD; Riny Janssen, PhD; Louis Bont, PhD, MD; Linde Meyaard, PhD

How to hold neutrophils in check
During RSV bronchiolitis neutrophils are the most abundant immune cells in the lung. Neutrophils are known to produce neutrophil extra cellular traps (NETs) which can induce injury to epithelial cells and hence contribute to disease severity. Neutrophils express several inhibitory receptors including LAIR-1. Whether targeting this receptor could diminish NET release is the question Geerdink and colleagues answer in their article. Their study demonstrates that sputum neutrophils from the lungs of RSV infected patients are highly activated and show increased LAIR-1 expression compared to blood derived neutrophils. More strikingly; targeting LAIR-1 with antibodies inhibited NET formation by 50%. This finding offers an innovative strategy that, together with newly developed antiviral, could contribute to the treatment of  RSV bronchiolitis.

To read the full article click here.​

​We are very proud to announce that our board member, Dr. Federico Martinón Torres and his team, designed a new clinical scale for infants with acute respiratory infection, the ReSVinet scale. Our scale is based on seven parameters (feeding intolerance, medical intervention, respiratory difficulty, respiratory frequency, apnoea, general condition, fever) that were assigned different values (from 0 to 3) for a total of 20 points. 170 children under two years of age with ARI were assessed independently by three pediatricians using this scale. 

​We invite you to read the full report by downloading the file via the link below

We would like to present a summary of the expert meeting by means of a short video. The video provides an impression of the presentations and the ambiance of the day. We sincerely hope you have enjoyed your stay, or will be encouraged to join us next time!  ​

We are proud to announce that Lancet Respiratory Medicine has published our article titled:
"LOWER RESPIRAROTY TRACT INFECTION CAUSED BY RESPIRATORY SYNCYTIAL VIRUS: CURRENT MANAGEMENT AND NEW THERAPEUTICS".
It is our pleasure to invite you to visit The Lancet website using the following link: http://www.thelancet.com/journals/lanres/onlinefirst

Please contact ReSViNET network manager Leyla Kragten-Tabatabaie (leyla.kragten@resvinet.org) if you would like to receive the full article as a .pdf document.