Sarah Geoghegan1*; Anabella Erviti1*; Mauricio T. Caballero1*; Fernando Vallone2; Stella M. Zanone1; Juan Ves Losada3; Alejandra Bianchi1; Patricio L. Acosta1; Laura B. Talarico1; Adrian Ferretti1; Luciano Alva Grimaldi4; Andrea Sancilio5; Karina Dueñas5; Gustavo Sastre6; Andrea Rodriguez 6 ; Fernando Ferrero7; Edgar Barboza8; Guadalupe Fernández Gago9; Celina Nocito10, Edgardo Flamenco11; Alberto Rodriguez Perez12; Beatriz Rebec13; F. Martin Ferolla1; Romina Libster1; Ruth A. Karron14; Eduardo Bergel1; Fernando P. Polack1,15
Respiratory syncytial virus (RSV) infection during infancy causes enormous mortality in the developing world. However, a good proportion of the mortality data have been derived from studies measuring excess mortality during RSV epidemics. Much of RSV-related deaths probably occur in the community due to lack of access to care. To understand individual characteristics of community-based and hospital-based deaths a prospective multicentre study was performed in Argentina. In hospitalized patients, case fatality was 0.9%. RSV infection explained about 50% of all deaths among infants presenting with lower respiratory tract illness. Death was related to bacterial sepsis and pneumothorax. This study is one of the first to provide insight into clinical characteristics of children dying from RSV and the mechanisms eventually preceding death.
High quality research is needed to improve patient care.